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Meanings of genetic instability in English
Russian
геномная нестабильность Spanish
inestabilidad genómica Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage.
Synonyms
Examples for "genome instability"
Examples for "genome instability"
1
Our present knowledge of the molecular basis underlying genome instability is extremely limited.
2
Here, we present evidence that MLL2 mutation results in genome instability.
3
Cells with a faulty protective mechanism undergo defective mitosis, leading to genome instability.
4
Human MLL2 knockout cells are characterized by genome instability as well.
5
Defects in the genes encoding the Paf1 complex can cause increased genome instability.
1
Cells from patients with genomic instability syndromes have high predisposition to cancer.
2
Deregulated activation of β-catenin in cancer has been correlated with genomic instability.
3
Moreover, the different patterns of alteration imply distinct underlying mechanisms of genomic instability.
4
NOS-induced ROS release leads to DNA damage and genomic instability in DMD hPSC.
5
Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability.
Usage of genetic instability in English
1
However, our data impressively demonstrate the genetic instability in this chromosomal region.
2
Oxidative DNA damage seems to contribute to genetic instability observed in cancer.
3
Background: Latent genetic instability has been associated with an increased risk for several cancers.
4
However, their inherent genetic instability hinders application for prophylactic purposes.
5
Defects in DNA damage responses may underlie genetic instability and malignant progression in melanoma.
6
Infected tax-expressing CD4+ lymphocytes accumulated cellular defects characteristic of genetic instability.
7
In addition, genetic instability is commonly seen.
8
This work also suggests how deficiencies in DNA damage detection systems can result in genetic instability and cancer.
9
In small compartments, genetic instability, which confers a selective disadvantage for the cell, can spread by random drift.
10
Background: Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome.
11
In addition, we describe genetic instability and exceptional phenotypic changes that accompany the evolution of these new LSC populations.
12
Thus, small compartments protect against mutations in tumor suppressor genes or oncogenes but promote the emergence of genetic instability.
13
P53 inactivation determines a condition of genetic instability, justifying the subsequent susceptibility to acquire mutations of different other genes.
14
For some unknown reason ( genetic instability?
15
Conclusion: Latent genetic instability as measured by the comet assay is associated with an increased estimated relative risk of bladder cancer.
16
ROS can stimulate cell proliferation, promote genetic instability, and induce adaptive responses that enable cancer cells to maintain their malignant phenotypes.
This collocation consists of:
Translations for genetic instability
Russian
Genetic instability through the time
Genetic instability across language varieties
United States of America
Common